Erhaltungstherapie mit Methadontabletten - Eine Übersicht
Erhaltungstherapie mit Methadontabletten - Eine Übersicht
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Methadone contains methadone, a mu-agonist opioid with an abuse liability similar to other opioid agonists and is a Schedule II controlled substance. Methadone and other opioids used rein analgesia have the potential for being abused and are subject to criminal diversion.
Methadone produces a significant regression of sex accessory organs and testes of male mice and rats. Additional data have been published indicating that methadone treatment of male rats (once a day for three consecutive days) increased embryolethality and neonatal mortality. Examination of uterine contents of methadone-naive female mice bred to methadone-treated mice indicated that methadone treatment produced an increase hinein the Satz of preimplantation deaths rein all Auf dem postweg-meiotic states.
There are conflicting reports on whether SIDS occurs with an increased incidence hinein infants born to women treated with methadone during pregnancy.
Geriatric – The pharmacokinetics of methadone have not been evaluated hinein the geriatric population.
For patients judged to Beryllium at risk, careful monitoring of cardiovascular Konstitution, including QT prolongation and dysrhythmias and those described previously should be performed.
Overdose in children warning: Children Weltgesundheitsorganisation accidentally take this drug have a high risk of death from overdosing. Children should not take this drug.
Abnormal fetal nonstress tests (NSTs) have been reported to occur more frequently when the test is performed 1 to 2 hours after a maintenance dose of methadone rein late pregnancy compared to controls.
These characteristics can contribute to cases of iatrogenic overdose, particularly during treatment Methadontabletten 10 mg online initiation and dose titration.
Do not drive, operate heavy machinery, or do other possible dangerous activities until you know how methadone hydrochloride tablets affect you. Methadone hydrochloride tablets can make you sleepy. Ask your doctor when it is okay to do these activities.
If it’s almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
The chance is higher if you are or have been addicted to or abused other medicines, street drugs, or alcohol, or if you have a history of mental problems.
Methadone hydrochloride tablets may not be right for you. Before starting methadone hydrochloride tablets, tell your doctor about all your medical and mental conditions including a history of drug or alcohol abuse or addiction.
Methadone has been detected hinein amniotic fluid and cord plasma at concentrations proportional to maternal plasma and in newborn urine at lower concentrations than corresponding maternal urine.
Respiratory depression is the chief hazard associated with methadone hydrochloride administration. Methadone's peak respiratory depressant effects typically occur later, and persist longer than its peak analgesic effects, particularly hinein the early dosing period.